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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP3K12
All Species:
20
Human Site:
S500
Identified Species:
36.67
UniProt:
Q12852
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q12852
NP_006292.2
859
93219
S500
R
N
V
P
Q
K
L
S
P
H
S
K
R
P
D
Chimpanzee
Pan troglodytes
XP_509099
871
93967
L514
P
H
P
S
R
G
L
L
H
G
N
T
M
E
K
Rhesus Macaque
Macaca mulatta
XP_001105474
890
96134
S533
R
N
V
P
Q
K
L
S
P
H
S
K
R
P
D
Dog
Lupus familis
XP_857182
860
93116
S500
R
N
V
P
Q
K
L
S
P
H
S
K
R
P
D
Cat
Felis silvestris
Mouse
Mus musculus
Q60700
888
96066
S533
R
N
V
P
Q
K
L
S
P
H
S
K
R
P
D
Rat
Rattus norvegicus
Q63796
888
96289
S533
R
N
V
P
Q
K
L
S
P
H
S
K
R
P
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422689
966
107967
G546
K
G
V
S
H
K
P
G
S
Q
T
K
R
P
D
Frog
Xenopus laevis
A7J1T0
961
107551
P546
K
G
P
P
S
R
V
P
S
Q
S
K
R
P
D
Zebra Danio
Brachydanio rerio
NP_996977
856
94429
N502
L
F
K
H
H
T
S
N
T
V
D
K
L
I
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q95UN8
1161
128942
A535
F
S
G
L
R
I
V
A
L
T
D
G
H
K
G
Honey Bee
Apis mellifera
XP_397605
895
101116
S519
R
N
P
Q
F
S
T
S
S
T
P
T
T
P
P
Nematode Worm
Caenorhab. elegans
O01700
928
103465
G524
E
D
V
Q
P
C
R
G
S
P
Y
R
C
S
N
Sea Urchin
Strong. purpuratus
XP_795085
943
105022
S519
S
L
Q
S
H
G
G
S
A
T
L
G
R
S
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.7
95.2
97.4
N.A.
92.5
91.7
N.A.
N.A.
52.3
51.8
65.4
N.A.
24
38.4
29
38.6
Protein Similarity:
100
95.8
95.6
98.5
N.A.
93.8
93.1
N.A.
N.A.
62.5
63.1
74
N.A.
38.4
52.8
44.9
52.8
P-Site Identity:
100
6.6
100
100
N.A.
100
100
N.A.
N.A.
40
40
6.6
N.A.
0
26.6
6.6
13.3
P-Site Similarity:
100
26.6
100
100
N.A.
100
100
N.A.
N.A.
53.3
60
13.3
N.A.
26.6
26.6
26.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
8
8
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
8
0
0
0
0
0
0
8
0
0
% C
% Asp:
0
8
0
0
0
0
0
0
0
0
16
0
0
0
54
% D
% Glu:
8
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% E
% Phe:
8
8
0
0
8
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
16
8
0
0
16
8
16
0
8
0
16
0
0
8
% G
% His:
0
8
0
8
24
0
0
0
8
39
0
0
8
0
0
% H
% Ile:
0
0
0
0
0
8
0
0
0
0
0
0
0
8
0
% I
% Lys:
16
0
8
0
0
47
0
0
0
0
0
62
0
8
16
% K
% Leu:
8
8
0
8
0
0
47
8
8
0
8
0
8
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% M
% Asn:
0
47
0
0
0
0
0
8
0
0
8
0
0
0
8
% N
% Pro:
8
0
24
47
8
0
8
8
39
8
8
0
0
62
16
% P
% Gln:
0
0
8
16
39
0
0
0
0
16
0
0
0
0
0
% Q
% Arg:
47
0
0
0
16
8
8
0
0
0
0
8
62
0
0
% R
% Ser:
8
8
0
24
8
8
8
54
31
0
47
0
0
16
0
% S
% Thr:
0
0
0
0
0
8
8
0
8
24
8
16
8
0
0
% T
% Val:
0
0
54
0
0
0
16
0
0
8
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _